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KMID : 1137820140350040105
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의공학회지
2014 Volume.35 No. 4 p.105 ~ p.110
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Feasibility Study on Magnetic Nanoparticle Hyperthermia in Low Field MRI
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Kim Ki-Soo
Cho Min-Hyoung
Lee Soo-Yeol
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Abstract
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For the combination of MRI and magnetic particle hyperthermia(MPH), we investigated the relative heating efficiency with respect to the strength of the static magnetic field under which the magnetic nanoparticles are to be heated by RF magnetic field. We performed nanoparticle heating experiments at the fringe field of 3T MRI magnet with applying the RF magnetic field perpendicularly to the static magnetic field. The static field strengths were 0T, 0.1T, 0.2T, and 0.3T. To prevent the coil heat from conducting to the nanoparticle suspension, we cooled the heating solenoid coil with temperature-controlled water with applying heat insulators between the solenoid coil and the nanoparticle container. We observed significant decrease of heat generation, up to 6% at 0.3T(100% at 0T), due to the magnetic saturation of the nanoparticles of 15 nm diameter under the static field. We think MPH is still feasible at low magnetic field lower than 0.3T if stronger RF magnetic field generation is permitted.
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KEYWORD
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magnetic particle hyperthermia(MPH), magnetic nanoparticle, solenoid coil, heating efficiency, MRI-guided MPH
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